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Cytosolic GR plays crucial roles in: Protecting cellular proteins from oxidative damage and maintaining their proper folding Supporting phase II detoxification pathways that require reduced glutathione as a cofactor Preserving the integrity of cellular membranes by preventing lipid peroxidation Modulating cell signaling pathways sensitive to redox status Defending against xenobiotic compounds that enter the cytoplasm The activity of cytosolic GR is tightly regulated and can be induced under conditions of oxidative stress, providing an adaptive response mechanism to increased free radical production

Non-pharmaceutical interventions (NPIs) ranging from social distancing, mask use in public spaces, and full-scale lockdowns, with travel bans at national and international borders, exerted a heavy toll on economic, educational, and social interactions

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